Ultimate Health Panel

$499.00

What

This annual physical panel contains: CBC (Complete Blood Count: Immune Cells, Red Blood Cells/Hematocrit, and Platelets) CMP (Comprehensive Metabolic Panel: Glucose, liver and kidney function, electrolyte and fluid balance) Lipids (LDL and HDL Cholesterol, and Triglycerides) Insulin Dehydroepiandrosterone (DHEA) A1C Test (Glycated Hemoglobin) Testosterone, Total, LC/MS and Free (Equilibrium Ultrafiltration) Ultrasensitive Estradiol Test Vitamin D Vitamin B12 Folate Iron TIBC Ferritin Cortisol TSH – Thyroid Stimulating Hormone Free T3 (Free Triiodothyronine Test) Free T4 (Free Thyroxine Test) Growth Hormone [IGF-1] High-Sensitivity CRP Apolipoprotein B Homocysteine

Who

Must be 18+ years of age to purchase Orders not permitted in: AK, HI, AZ

How

Type of samples to be collected: • Blood (venipuncture – a needle is used to draw blood from a vein) • Urine

Where

Schedule an appointment, then visit one of our Labcorp Patient Service Centers.

About This Test

Complete Blood Count (CBC test)

Whole blood is made up of various types of cells suspended in a liquid called plasma. The complete blood count (CBC) is an inventory of the different cellular components of the blood: red blood cells, white blood cells, and platelets. Blood cell counts are typically reported as the number of cells in a cubic millimeter of blood (cells/mm3) or as a percentage of all blood cells.

Comprehensive Metabolic Panel (CMP test)

The comprehensive metabolic panel or cmp panel consists of 14 blood tests which serve as an initial medical screening tool to review overall health. The CMP blood test panel functions as a check for kidney function, liver function, and electrolyte and fluid balance.

Lipid Panel (Cholesterol Test)

The lipid panel valuates the risk for developing atherosclerosis (arterial plaque) and coronary heart disease. This test includes: Total Cholesterol, Triglycerides, HDL Cholesterol, LDL Cholesterol, Total Cholesterol/HDL Ratio. This test requires fasting for 8 hours.

Insulin

Insulin is a substance produced by the pancreas to help stabilize blood sugar levels. This substance acts as a “key” that opens up the cells in your body, allowing them to absorb glucose and use it for energy production.

A typical insulin blood level between meals is 8–11 μIU/mL (57–79 pmol/L).

Dehydroepiandrosterone (DHEA)

Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal gland. It is also made in the brain. DHEA leads to the production of androgens and estrogens (male and female sex hormones). DHEA levels in the body begin to decrease after age 30. Levels decrease more quickly in women.

The adrenal glands also produce dehydroepiandrosterone (DHEA), the most abundant hormone found in the blood stream. DHEA is a hormone made by your adrenal glands and to a lesser degree by the ovaries and testes. DHEA is changed into DHEA-S in your adrenal glands and liver.

The body uses DHEA as the starting material for producing the sex hormones testosterone and estrogen. However, DHEA supplementation studies have shown that supplementation only increases testosterone in women. The production of DHEA diminishes in most people after age 40. In people aged 70 years, DHEA levels will be approximately 30 percent lower than what they were at age 25. Low blood levels of DHEA have been associated with many degenerative conditions.

Lower DHEA levels are found in people with hormonal disorders, HIV/AIDS, Alzheimer’s disease, heart disease, depression, diabetes, inflammation, immune disorders, and osteoporosis. Corticosteroids, birth control taken by mouth, and agents that treat psychiatric disorders may reduce DHEA levels.

A1C Test (Glycated Hemoglobin)

The A1c test works by measuring the hemoglobin A1c level. Hemoglobin is stored in the red blood cells. When glucose levels are high, the sugar starts to combine with the hemoglobin. It takes the body 8 to 12 weeks to bring hemoglobin A1c levels back to normal. Therefore, if hemoglobin A1c levels are high, that means that there has been a high level of glucose in the blood over the last 2 to 3 months.

Testosterone, Total, LC/MS and Free (Equilibrium Ultrafiltration)

This panel includes total testosterone measured by the most accurate method (liquid chromatography/mass spectrometry LC/MS), free testosterone percent by equilibrium dialysis/ultrafiltration, and free testosterone calculated from percent free T. It is adequate for men who expect high T levels and women (LC/MS is accurate for high and low T levels also).

Total Testosterone:

–   Liquid chromatography tandem mass spectrometry (LC/MS/MS)- No upper limit

–   Analytical sensitivity: 1.0 ng/dL

–   Analytical specificity: no cross-reactivity with other steroid compounds

–   Analytical Measurement Range: 1.0 ng/dL to 2,000 ng/dL

Free and Total Testosterone:

–   Percent free: equilibrium dialysis/ultrafiltration

–   Free: calculated based on total and percent free testosterone

Ultrasensitive Estradiol Test

Estradiol (Ultra-Sensitive LC/MS) is produced by the body via the aromatization of testosterone in fat tissue, liver, and testicles. Estradiol is involved in bone health, cognitive function, sex drive, and body composition in both men and women. Depending on lifestyle factors, liver issues, medications, body fat mass, and genetics, some people may have higher estradiol conversions from testosterone. The use of an ultra-sensitive, LC/MS assay for serum E2 measurement in males is preferred over direct immunoassays because of its greater sensitivity and lesser interference by other steroids. In males, estradiol is present at low concentrations in blood, but it is extraordinarily high in semen.  Estradiol plays an important function in sperm maturation and is essential for normal spermatogenesis and sperm motility. It is also essential for healthy bone density, body composition, lipids, and brain function. However, E2 excess in the presence of low testosterone and genetic factors can cause gynecomastia in some men.

The commonly used estradiol test may overestimate estradiol. That test uses immunoassay technology that cannot differentiate C-Reactive Protein (involved in inflammation) from estradiol, so it reads the combination of the two as estradiol. This overestimation can lead to excessive use of anastrozole that can result in low estradiol which can cause several health issues. This ultrasensitive estradiol test is based on liquid chromatography/mass spectrometry (LC/MS), an assay technology that does not have that limitation.

Vitamin D

Vitamin D is essential for bone health and many metabolic processes. The body derives it from sunlight and food sources. Many people do not get enough sunlight or do not consume enough vitamin D rich foods. This test is important to determine if you need vitamin D supplementation or if your current supplementation is effective.

Vitamin B12

Vitamin B12, also called cobalamin, is a water-soluble vitamin that has a key role in the normal functioning of the brain and nervous system, and the formation of red blood cells. It is one of eight B vitamins. It is involved in the metabolism of every cell of the human body, especially affecting DNA synthesis, fatty acid and amino acid metabolism. Humans are incapable of producing vitamin B12. Some substantial sources of B12 include animal products (shellfish, meat), fortified food products, and dietary supplements.

Folate

Folate is a water-soluble vitamin that is vital for human growth and the formation of red and white blood cells. Otherwise referred to as Vitamin B-9, folate is a particularly crucial nutrient for pregnant women as it can prevent fetal birth defects of the brain and spine. Folate is used in synthesizing DNA and RNA and plays a crucial role in breaking down amino acids.

Iron

Iron is an important mineral that your body needs to stay healthy. Your body uses iron to make hemoglobin, the protein in your red blood cells that carries oxygen throughout your body. If you don’t have enough iron, you may not have enough hemoglobin. This condition is called iron deficiency anemia.

Iron in your body is carried, or bound, mainly to a protein made by your liver called transferrin. The TIBC test is based on certain proteins, including transferrin, found in the blood. Your transferrin levels are almost always measured along with iron and TIBC.

Iron plays a principal role in erythropoiesis, the formation and maturation of red blood cells (RBCs) and is required for hemoglobin synthesis. The human body contains between four and five grams of iron, about 65% of which is present in hemoglobin and 3% of which is present in myoglobin, the oxygen storage protein found in skeletal muscle and cardiac muscle. A small amount is also found in cellular enzymes that catalyze the oxidation and reduction of iron. Excess iron is stored in the liver and spleen as ferritin and hemosiderin. Any iron present in the serum is in transit between the digestive track and bone marrow, and available iron stores forms. Sixty to 70% of the body’s iron is carried by its specific transport protein, transferrin. For this reason, total iron binding capacity (TIBC) and transferrin are sometimes referred to interchangeable, even though other proteins carry iron and contribute to the TIBC.

Unbound iron is highly toxic, but there is generally an excess of transferrin available to prevent the buildup of unbound iron in the circulation. The percentage of iron saturation is calculated by dividing the serum iron value by the TIBC value and multiplying it by 100.

TIBC

  • Assist in the diagnosis of iron deficiency anemia.
  • Differentiate between iron deficiency anemia and anemia secondary to chronic disease.
  • Monitor hematological response to therapy during pregnancy and iron deficiency anemias.
  • Provide support for diagnosis of hemochromatosis or diseases of iron metabolism and storage.

Ferritin

Ferritin is a protein found in the bloodstream which stores iron. Ferritin helps in transporting iron where it’s most needed in the body. Too much or too little ferritin can cause a lot of health issues and that’s why you should check it often.

Cortisol

Cortisol (hydrocortisone) is the most prominent glucocorticosteroid, and it is essential for the maintenance of several body functions. Like other glucocorticosteroids, cortisol is synthesized from the common precursor cholesterol in the zona fasciculata of the cortex of the adrenal gland. For the transport of cortisol in blood, about 90% of cortisol is bound to corticosteroid-binding globulin (CBG) and to albumin. Only a small amount of cortisol circulates unbound in blood and is free to interact with its receptors.

TSH – Thyroid Stimulating Hormone

The thyroid-stimulating hormone is the best and most common test to check the possibility of thyroid disease in the context of nonexistent dysfunction of the pituitary gland. If this test gives normal values, 0.450−4.500 μIU/mL (>10 yr old) it means that the TSH levels are in the normal range.

An increased level of TSH may suggest that the pituitary gland sends a message that the deficit thyroid does not produce enough hormones which leads to hypothyroidism.

By comparison, if the TSH level is very low, it means that a higher number of hormones was produced and you may suffer from hyperthyroidism.

Free T3 (Free Triiodothyronine Test)

The test for this hormone is usually useful to determine whether a patient suffers from hyperthyroidism or not. Normal levels for T3 lie between 100 and 200 ng/Dl.

Whenever you are facing symptoms such as constipation, anxiety, depression, dry skin, increased heart rate, or sleeping disorders, a test may be required.

Free T4 (Free Thyroxine Test)

The thyroid gland secretes and produces T4 which is well known as thyroxine. The thyroxine binds with the proteins and arrives in your tissues throughout the bloodstream.

Further on, the T4 and the proteins split and T4 becomes free to convert itself in T3, a more active form. In general, doctors recommend testing both TSH and free T4 to get to a clearer picture in case of hypothyroidism. The reference interval for this indicator is 0.82-1.77 ng/dl (>19 years old).

Growth Hormone [IGF-1]

IGF-1 is a hormone produced in our body that is structurally very similar to insulin. It has an important role in growth during childhood and in adulthood, continues to have anabolic effects. IGF-1 is the main mediator of the effects of growth hormone, which, most of us know, can benefit male physique drastically and also has anti-aging effects.

High-Sensitivity CRP

The high-sensitivity C-reactive protein (hs-CRP) test is a blood test that measures the level of hs-CRP in the blood. CRP is a protein produced by the liver that increases in response to inflammation in the body. The hs-CRP test is a more sensitive version of the CRP test, meaning it can detect lower levels of CRP in the blood.

High levels of hs-CRP in the blood may be a sign of inflammation in the body, which can be caused by various conditions, such as infections, injuries, autoimmune disorders, and certain chronic diseases. The hs-CRP test is often used to help evaluate a person’s risk of developing cardiovascular disease, as high levels of hs-CRP have been associated with an increased risk of heart attack and stroke. A healthcare provider usually orders the hs-CRP test as part of a routine health check-up or if they suspect a person may have inflammation in the body.

Apolipoprotein B

Apolipoprotein B (APO B) Test has been reported to be a powerful indicator of Coronary Artery Disease (CAD). In some patients with CAD, APO B is elevated even in the presence of normal LDL cholesterol.

The apolipoprotein B (apo B) test is used, along with other lipid tests, to help determine an individual’s risk of developing cardiovascular disease (CVD).

This test is not used as a general population screen but may be ordered if a person has a family history of heart disease and/or high cholesterol and triglycerides (hyperlipidemia). It may be performed, along with other tests, to help diagnose the cause of abnormal lipid levels, especially when someone has elevated triglyceride levels.

Homocysteine

Homocysteine is an amino acid produced when proteins in your body are broken down. Normal levels of homocysteine don’t affect your health and don’t produce symptoms. However, higher levels of this substance should concern you.

Elevated levels of homocysteine can lead to blood clots and atherosclerosis. This means that blockages can develop in your circulatory system. Similarly, atherosclerosis is the process of narrowing blood vessels and arteries. This could lead to hypertension and other serious health problems.

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